“Candida auris Outsmarts Antifungals by Duplicating Entire Genome, Study Finds” — what this page in the network covers. The drug-resistant fungus Candida auris, a growing threat in hospitals worldwide, has a new trick up its sleeve: it copies its entire genome to survive antifungal treatment, according to new research from the University of Exeter and City St George's, University of London. auris can create multiple versions of its genome, including mutations in a gene called CRZ1, which is crucial for maintaining cell wall integrity. This genomic duplication is an unexpected mechanism that helps the fungus resist drugs like fluconazole and amphotericin B.
auris is notorious for causing severe infections with high mortality rates, particularly in immunocompromised patients, and its ability to rapidly develop resistance has puzzled scientists. By understanding how the fungus adapts at the genetic level, researchers hope to develop better diagnostic tools and targeted therapies. The full version stays on the original page, which this listing opens directly.